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OSATCode: 110

OSAT Biological Sciences (110) Practice Tests

Prepare for the OSAT Biological Sciences (110): 80 selected-response questions and 1 constructed-response assignment in 4 hours, covering 4 content areas: Structures and Processes of Cells and Organisms (33%), Ecosystem Energy Flow, Interactions, and Dynamics (26%), Heredity and Evolution (26%) and Constructed-Response Assignment (15%).

81
Questions
4h
Time limit
240
Pass score
4
Domains
4.9 · 12,400

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Source: All exam details are drawn from official examination program websites and state educator certification agency documentation. Most state licensure exams are developed and administered by Evaluation Systems of Pearson (nesinc.com) on behalf of state departments of education. Always verify current requirements with your state's teacher certification agency.

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OSAT Biological Sciences (110): Test at a Glance

Facts as published by the official test program.

The OSAT Biological Sciences (110) test has 80 selected-response questions and 1 constructed-response assignment and 4 hours of testing time at a test center (3 hours with online proctoring), not including the 15-minute tutorial. The passing score is 240 on the 100 to 300 scale.

Its subareas are Structures and Processes of Cells and Organisms (33%), Ecosystem Energy Flow, Interactions, and Dynamics (26%), Heredity and Evolution (26%), Constructed-Response Assignment (15%). The official study guide lists 11 competencies across them.

Oklahoma educator certification is handled by the Oklahoma State Department of Education (OSDE). Confirm with the OSDE or your preparation program which Oklahoma subject area tests your certificate requires. If you are certifying through an alternative route, contact the OSDE before you register.

In round numbers, the weights of the selected-response subareas mean roughly this many of the 80 selected-response questions: Structures and Processes of Cells and Organisms (about 31), Ecosystem Energy Flow, Interactions, and Dynamics (about 24), Heredity and Evolution (about 24). The study guide calls the percentages approximate, so treat them as a planning guide rather than an exact count.

The constructed-response assignment is a written response that qualified Oklahoma educators score against a rubric, separately from the machine-scored selected-response questions. 15% of the test score comes from it, so a weak written response costs real points.

Passing score: A scaled score of 240 (scale 100 to 300).

Test code
110
Questions
81
80 selected-response questions and 1 constructed-response assignment
Testing time
4 hours
4 hours, not including the 15-minute tutorial
Format
Computer-based test; some tests also online proctored
Test center; online proctoring for some tests
Passing score
240
A scaled score of 240 (scale 100 to 300)
Test fee
$118
Test fee

OSAT Biological Sciences (110): Exam Blueprint

Content categories and approximate weighting from the official test framework.

1. Structures and Processes of Cells and Organisms

33%

Competencies 0001–0004 make up about 33% of the test. They ask you to understand the characteristics and biochemistry of the atoms and molecules necessary for life; understand the characteristics of cells and their structures and processes; understand photosynthesis, cellular respiration, and the flow of energy and matter in cells, and more.

  • Competency 0001: Understand the characteristics and biochemistry of the atoms and molecules necessary for life. Skills tested: Demonstrate knowledge of the characteristics and roles of common elements in living organisms (i.e., hydrogen, carbon, nitrogen, sulfur, oxygen, and phosphorous) and the properties of hydrogen, ionic, and covalent bonds; Demonstrate knowledge of the structures and functions of important macromolecules (i.e., carbohydrates, lipids, proteins, and nucleic acids), their building blocks, and the significance of hydrolysis and dehydration synthesis reactions; Analyze the properties of water and the significance of these properties to living organisms; Apply knowledge of the relationship between the structure of DNA and RNA, including their functions; Apply knowledge of the relationship of structure and function to proteins, including enzymes, and the characteristics of enzyme action; Apply knowledge of OASS science and engineering practices related to the characteristics and biochemistry of the atoms and molecules necessary for life; Demonstrate knowledge of OASS crosscutting concepts between the characteristics and biochemistry of the atoms and molecules necessary for life and topics in biology and other scientific fields.
  • Competency 0002: Understand the characteristics of cells and their structures and processes. Skills tested: Demonstrate knowledge of cell theory, the characteristics and structures of various cells (e.g., prokaryotic cells, animal cells, plants cells, protists), and nonliving cell-like structures (e.g., viruses); Apply knowledge of the primary structure and function of various cellular structures (e.g., lysosomes, microtubules, cell membranes), including their interactions and involvement in cellular processes; Apply knowledge of the process of cell differentiation and the roles specialized cells play in the life-sustaining functions of multicellular organisms; Demonstrate knowledge of the importance of active and passive transport in maintaining homeostasis in cells and the relationships between these processes and cellular membranes; Demonstrate knowledge of types of cellular communication (e.g., endocrine, synaptic transmission, hormonal); Demonstrate knowledge of the eukaryotic cell cycle, including major events (e.g., DNA replication, mitosis, cytokinesis); Apply knowledge of how the events of the eukaryotic cell cycle are related to growth, maintenance, and repair, including the relationship of these events with the occurrence of cancer in organisms; Demonstrate knowledge of the differences between the processes of mitosis and meiosis, including their major events, functions, products, and errors (e.g., deletions, transmutations, inversions); Apply knowledge of OASS science and engineering practices related to the characteristics of cells and their structures and processes; Demonstrate knowledge of OASS crosscutting concepts between the characteristics of cells and their structures and processes and topics in biology and other scientific fields.
  • Competency 0003: Understand photosynthesis, cellular respiration, and the flow of energy and matter in cells. Skills tested: Demonstrate an understanding of the sources of energy used by various types of organisms (e.g., archaea, bacteria, plants, animals); Demonstrate an understanding of photosynthesis, including the inputs and outputs of this process and the energy and matter transformations that occur; Apply knowledge of the process of cellular respiration and ATP production in aerobic and anaerobic conditions, including the factors that affect energy yield and storage; Apply knowledge of the significance of chloroplast and mitochondrion structure in relation to the processes of photosynthesis and respiration and of biochemical pathways of photosynthesis and respiration (e.g., Calvin cycle, glycolysis, Krebs cycle), including through the use of models; Apply knowledge of OASS science and engineering practices related to photosynthesis, cellular respiration, and the flow of energy and matter in cells; Demonstrate knowledge of OASS crosscutting concepts between the processes of photosynthesis, cellular respiration, and the flow of energy and matter in cells and topics in biology and other scientific fields.
  • Competency 0004: Understand organismal maintenance, growth, and reproduction. Skills tested: Demonstrate knowledge of the characteristics of living organisms (e.g., differences between organisms and nonliving things) and the requirements needed to sustain life; Apply knowledge of the hierarchical organization of cells, tissues, organs, and organ systems in living organisms (e.g., blood and vessels of the circulatory system, xylem and phloem of the transport system), including those involved in maintaining homeostasis; Demonstrate knowledge of the physiological processes needed for the maintenance, growth, and reproduction in plants; Demonstrate knowledge of the physiological processes needed for the maintenance, growth, and reproduction in animals, including humans; Analyze the behavioral responses of organisms to internal and external stimuli (e.g., light, gravity, chemical concentrations) and the adaptive significance of these behaviors; Apply knowledge of the life cycles and development of various types of model organisms (e.g., insect, plant, vertebrate); Apply knowledge of OASS science and engineering practices related to organismal maintenance, growth, and reproduction; Demonstrate knowledge of OASS crosscutting concepts between organismal maintenance, growth, and reproduction and topics in biology and other scientific fields.

2. Ecosystem Energy Flow, Interactions, and Dynamics

26%

Competencies 0005–0007 make up about 26% of the test. They ask you to understand the characteristics of biomes, ecosystems, and their inhabitants; understand the flow of matter and energy in organisms and ecosystems; understand the impact of human activities on the environment and society.

  • Competency 0005: Understand the characteristics of biomes, ecosystems, and their inhabitants. Skills tested: Analyze relationships among organisms in a community (e.g., competition, predation, parasitism); Demonstrate knowledge of the characteristics of major types of biomes (e.g., terrestrial, aquatic) and ecosystems and their components (e.g., flora, fauna), including the abiotic and biotic factors that shape these types of communities; Demonstrate an understanding of factors that affect population size and growth rate (e.g., carrying capacity, limiting factors) and the use of sampling methods and mathematical models (e.g., growth curves) related to characteristics of populations; Apply knowledge of the process of ecological succession and stability and change in ecosystems in response to variations in abiotic and biotic factors; Analyze the effect of biome degradation and destruction (e.g., climate changes, deforestation, introduction of invasive species) on individual species, ecological relationships, and biosphere stability; Apply knowledge of OASS science and engineering practices related to the characteristics of biomes, ecosystems, and their inhabitants; Demonstrate knowledge of OASS crosscutting concepts between the characteristics of biomes, ecosystems, and their inhabitants and topics in biology and other scientific fields.
  • Competency 0006: Understand the flow of matter and energy in organisms and ecosystems. Skills tested: Analyze the ways in which organisms obtain, transform, transport, and release matter and energy; Analyze the implications of the conservation of energy and matter for living systems; Demonstrate an understanding of the relationships of organisms in ecosystems (e.g., primary producers, consumers, decomposers); Demonstrate an understanding of how energy and matter move through the trophic levels of ecosystems (e.g., 10% rule); Compare the strengths and limitations of pyramid and web models (e.g., biomass, numbers, energy) and their representation of the flow of matter and energy in ecosystems; Apply knowledge of biogeochemical cycles (e.g., carbon, nitrogen, phosphorous, water) and the movement of matter through abiotic and biotic reservoirs in ecosystems, including the use of models; Demonstrate an understanding of the role of bacteria in nutrient cycling in ecosystems (e.g., nitrogen fixation, decomposition, weathering of rock, photosynthesis); Apply knowledge of OASS science and engineering practices related to the flow of matter and energy in organisms and ecosystems; Demonstrate knowledge of OASS crosscutting concepts between the flow of matter and energy in organisms and ecosystems and topics in biology and other scientific fields.
  • Competency 0007: Understand the impact of human activities on the environment and society. Skills tested: Apply knowledge of renewable and nonrenewable resources and the long- and short-term effects on the environment that result from their use; Demonstrate knowledge of the types and sources of environmental pollution; the effects of pollution on natural populations, communities, and ecosystems; and remediation methods; Analyze recent developments in biology and biotechnology (e.g., medical technology, genetic engineering, wastewater treatment), including their societal implications; Analyze the role of science and technology in local, national, and global challenges (e.g., habitat fragmentation, introduction of invasive species, overharvesting, acid rain), including the methods for preventing, mitigating, and reversing the impacts caused by human activities on the environment; Demonstrate knowledge of the importance and implications of influencing factors (e.g., nutrition, public health, loss of ecosystem services) on human population dynamics, including the use of models; Apply knowledge of OASS science and engineering practices related to the impact of human activities on the environment and society; Demonstrate knowledge of OASS crosscutting concepts between the impact of human activities on the environment and society and topics in biology and other scientific fields.

3. Heredity and Evolution

26%

Competencies 0008–0010 make up about 26% of the test. They ask you to understand the molecular basis of inheritance; understand the inheritance and variation of traits; understand natural selection, adaptation, and the diversity of life.

  • Competency 0008: Understand the molecular basis of inheritance. Skills tested: Demonstrate knowledge of the structure of and the relationship between DNA, alleles, genes, and chromosomes; Apply knowledge of the mechanism of DNA replication and the types and causes of mutations that can occur during this process; Apply knowledge of protein synthesis, including the processes of transcription and translation and the structure and function of mRNA and tRNA; Demonstrate an understanding of the control of gene expression in prokaryotes (e.g., lac operon in E. coli) and in eukaryotes; Demonstrate an understanding of genetic engineering techniques and tools (e.g., electrophoresis, sequencing, using bacterial plasmids) and their roles in the basic discoveries of molecular genetics; Apply knowledge of the role of genetic engineering in the production of valuable medical treatments and commercial products (e.g., human insulin, genetically modified organisms, CRISPR-Cas9); Apply knowledge of OASS science and engineering practices related to the molecular basis of inheritance; Demonstrate knowledge of OASS crosscutting concepts between the molecular basis of inheritance and topics in biology and other scientific fields.
  • Competency 0009: Understand the inheritance and variation of traits. Skills tested: Apply knowledge of the roles of DNA, RNA, genes, and chromosomal behavior, including on patterns of inheritance of traits (e.g., codominance, sex linkage, multiple alleles, polygenic traits); Analyze the significance of historic pea plant experiments and their implications regarding basic principles of heredity (e.g., unit factors, dominance, segregation, independent assortment); Apply knowledge of genetics to explain connections between genotype and phenotype, including the use of models (e.g., Punnett squares, pedigree charts); Apply principles of probability to genotype and phenotype combinations in offspring, including for traits that are complete dominant, incomplete dominant, codominant, sex linked, and polygenic; Demonstrate an understanding of the role of nonnuclear inheritance (e.g., mitochondrial DNA, chloroplast DNA); Demonstrate knowledge of the sources and types of mutations leading to genetic disorders (e.g., PKU, cystic fibrosis, sickle cell anemia) and the techniques used to determine the presence of human genetic diseases; Apply knowledge of OASS science and engineering practices related to the inheritance and variation of traits; Demonstrate knowledge of OASS crosscutting concepts between the inheritance and variation of traits and topics in biology and other scientific fields.
  • Competency 0010: Understand natural selection, adaptation, and the diversity of life. Skills tested: Demonstrate knowledge of the theory of evolution and of natural selection; Analyze proposed mechanisms of evolution (e.g., gradualism, punctuated equilibrium) and the scientific evidence supporting evolutionary change (e.g., fossil record, comparative anatomy, biochemistry, molecular biology, drug-resistant bacteria); Apply knowledge of the factors necessary for adaptation to occur (e.g., genetic variation, phenotypic variation, survival of the fittest), including the cause-and-effect relationship between natural selection and adaptation; Analyze the adaptive significance of various reproductive strategies (e.g., development of seeds, internal fertilization), including the influence of group behavior on reproduction and the comparison of asexual and sexual reproduction; Demonstrate knowledge of the factors that contribute to speciation (e.g., geographic isolation, reproductive isolation); Apply knowledge of population genetics and the factors that affect the frequencies of alleles in a population over time (e.g., natural selection, genetic drift, gene flow) to explain evolutionary change or stasis in populations; Demonstrate knowledge of basic taxonomy, criteria used to classify organisms, (e.g., morphology, biochemical comparisons, dichotomous keys), and biological systematics and models (e.g., binomial nomenclature, phylogenetic trees, cladograms); Apply knowledge of OASS science and engineering practices related to natural selection, adaptation, and the diversity of life; Demonstrate knowledge of OASS crosscutting concepts between natural selection, adaptation, and the diversity of life and topics in biology and other scientific fields.

4. Constructed-Response Assignment

15%

Competency 0011 makes up about 15% of the test. They ask you to analyze a lesson plan and student work sample for a learning standard in the Oklahoma Academic Standards for Science or the Next Generation Science Standards and describe differentiated instructional strategies that address student needs. Constructed-response assignment.

  • Competency 0011: Analyze a lesson plan and student work sample for a learning standard in the Oklahoma Academic Standards for Science or the Next Generation Science Standards and describe differentiated instructional strategies that address student needs. Skills tested: Apply knowledge of standards-based learning goals for biology content; Analyze student work samples from a biology lesson, citing specific evidence to identify strengths and needs; Describe differentiated instructional strategies based on identified strengths and needs; Describe the potential impacts of this analysis on future instruction for specific students, for specific units of study, and for a teacher's general instructional practice.

Study Guide by Content Category

Use this section to plan your study time. Each topic comes from the official content categories for OSAT Biological Sciences (110).

Category 1 · Structures and Processes of Cells and Organisms

About 33% of the exam
  • Understand the characteristics and biochemistry of the atoms and molecules necessary for life. Review Demonstrate knowledge of the characteristics and roles of common elements in living organisms (i.e., hydrogen, carbon, nitrogen, sulfur, oxygen, and phosphorous) and the properties of hydrogen, ionic, and covalent bonds; Demonstrate knowledge of the structures and functions of important macromolecules (i.e., carbohydrates, lipids, proteins, and nucleic acids), their building blocks, and the significance of hydrolysis and dehydration synthesis reactions; Analyze the properties of water and the significance of these properties to living organisms; Apply knowledge of the relationship between the structure of DNA and RNA, including their functions; Apply knowledge of the relationship of structure and function to proteins, including enzymes, and the characteristics of enzyme action; Apply knowledge of OASS science and engineering practices related to the characteristics and biochemistry of the atoms and molecules necessary for life.
  • More on understand the characteristics and biochemistry of the atoms and molecules necessary for life. Also review Demonstrate knowledge of OASS crosscutting concepts between the characteristics and biochemistry of the atoms and molecules necessary for life and topics in biology and other scientific fields.
  • Understand the characteristics of cells and their structures and processes. Review Demonstrate knowledge of cell theory, the characteristics and structures of various cells (e.g., prokaryotic cells, animal cells, plants cells, protists), and nonliving cell-like structures (e.g., viruses); Apply knowledge of the primary structure and function of various cellular structures (e.g., lysosomes, microtubules, cell membranes), including their interactions and involvement in cellular processes; Apply knowledge of the process of cell differentiation and the roles specialized cells play in the life-sustaining functions of multicellular organisms; Demonstrate knowledge of the importance of active and passive transport in maintaining homeostasis in cells and the relationships between these processes and cellular membranes; Demonstrate knowledge of types of cellular communication (e.g., endocrine, synaptic transmission, hormonal); Demonstrate knowledge of the eukaryotic cell cycle, including major events (e.g., DNA replication, mitosis, cytokinesis).
  • More on understand the characteristics of cells and their structures and processes. Also review Apply knowledge of how the events of the eukaryotic cell cycle are related to growth, maintenance, and repair, including the relationship of these events with the occurrence of cancer in organisms; Demonstrate knowledge of the differences between the processes of mitosis and meiosis, including their major events, functions, products, and errors (e.g., deletions, transmutations, inversions); Apply knowledge of OASS science and engineering practices related to the characteristics of cells and their structures and processes; Demonstrate knowledge of OASS crosscutting concepts between the characteristics of cells and their structures and processes and topics in biology and other scientific fields.
  • Understand photosynthesis, cellular respiration, and the flow of energy and matter in cells. Review Demonstrate an understanding of the sources of energy used by various types of organisms (e.g., archaea, bacteria, plants, animals); Demonstrate an understanding of photosynthesis, including the inputs and outputs of this process and the energy and matter transformations that occur; Apply knowledge of the process of cellular respiration and ATP production in aerobic and anaerobic conditions, including the factors that affect energy yield and storage; Apply knowledge of the significance of chloroplast and mitochondrion structure in relation to the processes of photosynthesis and respiration and of biochemical pathways of photosynthesis and respiration (e.g., Calvin cycle, glycolysis, Krebs cycle), including through the use of models; Apply knowledge of OASS science and engineering practices related to photosynthesis, cellular respiration, and the flow of energy and matter in cells; Demonstrate knowledge of OASS crosscutting concepts between the processes of photosynthesis, cellular respiration, and the flow of energy and matter in cells and topics in biology and other scientific fields.
  • Understand organismal maintenance, growth, and reproduction. Review Demonstrate knowledge of the characteristics of living organisms (e.g., differences between organisms and nonliving things) and the requirements needed to sustain life; Apply knowledge of the hierarchical organization of cells, tissues, organs, and organ systems in living organisms (e.g., blood and vessels of the circulatory system, xylem and phloem of the transport system), including those involved in maintaining homeostasis; Demonstrate knowledge of the physiological processes needed for the maintenance, growth, and reproduction in plants; Demonstrate knowledge of the physiological processes needed for the maintenance, growth, and reproduction in animals, including humans; Analyze the behavioral responses of organisms to internal and external stimuli (e.g., light, gravity, chemical concentrations) and the adaptive significance of these behaviors; Apply knowledge of the life cycles and development of various types of model organisms (e.g., insect, plant, vertebrate).
  • More on understand organismal maintenance, growth, and reproduction. Also review Apply knowledge of OASS science and engineering practices related to organismal maintenance, growth, and reproduction; Demonstrate knowledge of OASS crosscutting concepts between organismal maintenance, growth, and reproduction and topics in biology and other scientific fields.

Category 2 · Ecosystem Energy Flow, Interactions, and Dynamics

About 26% of the exam
  • Understand the characteristics of biomes, ecosystems, and their inhabitants. Review Analyze relationships among organisms in a community (e.g., competition, predation, parasitism); Demonstrate knowledge of the characteristics of major types of biomes (e.g., terrestrial, aquatic) and ecosystems and their components (e.g., flora, fauna), including the abiotic and biotic factors that shape these types of communities; Demonstrate an understanding of factors that affect population size and growth rate (e.g., carrying capacity, limiting factors) and the use of sampling methods and mathematical models (e.g., growth curves) related to characteristics of populations; Apply knowledge of the process of ecological succession and stability and change in ecosystems in response to variations in abiotic and biotic factors; Analyze the effect of biome degradation and destruction (e.g., climate changes, deforestation, introduction of invasive species) on individual species, ecological relationships, and biosphere stability; Apply knowledge of OASS science and engineering practices related to the characteristics of biomes, ecosystems, and their inhabitants.
  • More on understand the characteristics of biomes, ecosystems, and their inhabitants. Also review Demonstrate knowledge of OASS crosscutting concepts between the characteristics of biomes, ecosystems, and their inhabitants and topics in biology and other scientific fields.
  • Understand the flow of matter and energy in organisms and ecosystems. Review Analyze the ways in which organisms obtain, transform, transport, and release matter and energy; Analyze the implications of the conservation of energy and matter for living systems; Demonstrate an understanding of the relationships of organisms in ecosystems (e.g., primary producers, consumers, decomposers); Demonstrate an understanding of how energy and matter move through the trophic levels of ecosystems (e.g., 10% rule); Compare the strengths and limitations of pyramid and web models (e.g., biomass, numbers, energy) and their representation of the flow of matter and energy in ecosystems; Apply knowledge of biogeochemical cycles (e.g., carbon, nitrogen, phosphorous, water) and the movement of matter through abiotic and biotic reservoirs in ecosystems, including the use of models.
  • More on understand the flow of matter and energy in organisms and ecosystems. Also review Demonstrate an understanding of the role of bacteria in nutrient cycling in ecosystems (e.g., nitrogen fixation, decomposition, weathering of rock, photosynthesis); Apply knowledge of OASS science and engineering practices related to the flow of matter and energy in organisms and ecosystems; Demonstrate knowledge of OASS crosscutting concepts between the flow of matter and energy in organisms and ecosystems and topics in biology and other scientific fields.
  • Understand the impact of human activities on the environment and society. Review Apply knowledge of renewable and nonrenewable resources and the long- and short-term effects on the environment that result from their use; Demonstrate knowledge of the types and sources of environmental pollution; the effects of pollution on natural populations, communities, and ecosystems; and remediation methods; Analyze recent developments in biology and biotechnology (e.g., medical technology, genetic engineering, wastewater treatment), including their societal implications; Analyze the role of science and technology in local, national, and global challenges (e.g., habitat fragmentation, introduction of invasive species, overharvesting, acid rain), including the methods for preventing, mitigating, and reversing the impacts caused by human activities on the environment; Demonstrate knowledge of the importance and implications of influencing factors (e.g., nutrition, public health, loss of ecosystem services) on human population dynamics, including the use of models; Apply knowledge of OASS science and engineering practices related to the impact of human activities on the environment and society.
  • More on understand the impact of human activities on the environment and society. Also review Demonstrate knowledge of OASS crosscutting concepts between the impact of human activities on the environment and society and topics in biology and other scientific fields.

Category 3 · Heredity and Evolution

About 26% of the exam
  • Understand the molecular basis of inheritance. Review Demonstrate knowledge of the structure of and the relationship between DNA, alleles, genes, and chromosomes; Apply knowledge of the mechanism of DNA replication and the types and causes of mutations that can occur during this process; Apply knowledge of protein synthesis, including the processes of transcription and translation and the structure and function of mRNA and tRNA; Demonstrate an understanding of the control of gene expression in prokaryotes (e.g., lac operon in E. coli) and in eukaryotes; Demonstrate an understanding of genetic engineering techniques and tools (e.g., electrophoresis, sequencing, using bacterial plasmids) and their roles in the basic discoveries of molecular genetics; Apply knowledge of the role of genetic engineering in the production of valuable medical treatments and commercial products (e.g., human insulin, genetically modified organisms, CRISPR-Cas9).
  • More on understand the molecular basis of inheritance. Also review Apply knowledge of OASS science and engineering practices related to the molecular basis of inheritance; Demonstrate knowledge of OASS crosscutting concepts between the molecular basis of inheritance and topics in biology and other scientific fields.
  • Understand the inheritance and variation of traits. Review Apply knowledge of the roles of DNA, RNA, genes, and chromosomal behavior, including on patterns of inheritance of traits (e.g., codominance, sex linkage, multiple alleles, polygenic traits); Analyze the significance of historic pea plant experiments and their implications regarding basic principles of heredity (e.g., unit factors, dominance, segregation, independent assortment); Apply knowledge of genetics to explain connections between genotype and phenotype, including the use of models (e.g., Punnett squares, pedigree charts); Apply principles of probability to genotype and phenotype combinations in offspring, including for traits that are complete dominant, incomplete dominant, codominant, sex linked, and polygenic; Demonstrate an understanding of the role of nonnuclear inheritance (e.g., mitochondrial DNA, chloroplast DNA); Demonstrate knowledge of the sources and types of mutations leading to genetic disorders (e.g., PKU, cystic fibrosis, sickle cell anemia) and the techniques used to determine the presence of human genetic diseases.
  • More on understand the inheritance and variation of traits. Also review Apply knowledge of OASS science and engineering practices related to the inheritance and variation of traits; Demonstrate knowledge of OASS crosscutting concepts between the inheritance and variation of traits and topics in biology and other scientific fields.
  • Understand natural selection, adaptation, and the diversity of life. Review Demonstrate knowledge of the theory of evolution and of natural selection; Analyze proposed mechanisms of evolution (e.g., gradualism, punctuated equilibrium) and the scientific evidence supporting evolutionary change (e.g., fossil record, comparative anatomy, biochemistry, molecular biology, drug-resistant bacteria); Apply knowledge of the factors necessary for adaptation to occur (e.g., genetic variation, phenotypic variation, survival of the fittest), including the cause-and-effect relationship between natural selection and adaptation; Analyze the adaptive significance of various reproductive strategies (e.g., development of seeds, internal fertilization), including the influence of group behavior on reproduction and the comparison of asexual and sexual reproduction; Demonstrate knowledge of the factors that contribute to speciation (e.g., geographic isolation, reproductive isolation); Apply knowledge of population genetics and the factors that affect the frequencies of alleles in a population over time (e.g., natural selection, genetic drift, gene flow) to explain evolutionary change or stasis in populations.
  • More on understand natural selection, adaptation, and the diversity of life. Also review Demonstrate knowledge of basic taxonomy, criteria used to classify organisms, (e.g., morphology, biochemical comparisons, dichotomous keys), and biological systematics and models (e.g., binomial nomenclature, phylogenetic trees, cladograms); Apply knowledge of OASS science and engineering practices related to natural selection, adaptation, and the diversity of life; Demonstrate knowledge of OASS crosscutting concepts between natural selection, adaptation, and the diversity of life and topics in biology and other scientific fields.

Category 4 · Constructed-Response Assignment

About 15% of the exam
  • Analyze a lesson plan and student work sample for a learning standard in the Oklahoma Academic Standards for Science or the Next Generation Science Standards and describe differentiated instructional strategies that address student needs. Review Apply knowledge of standards-based learning goals for biology content; Analyze student work samples from a biology lesson, citing specific evidence to identify strengths and needs; Describe differentiated instructional strategies based on identified strengths and needs.
  • analyze a lesson plan and student work sample for a learning standard in the Oklahoma Academic Standards for Science or the Next Generation Science Standards and describe differentiated instructional strategies that address student needs, continued. Also review Describe the potential impacts of this analysis on future instruction for specific students, for specific units of study, and for a teacher's general instructional practice.

Registration, Test Day and Scoring

Test options
Test center; some tests also offer online proctoring
Passing score
240 (scale 100-300)

How to Register

  1. 1
    Confirm which test you need

    The Oklahoma State Department of Education and your preparation program decide which subject area test applies to your certificate. Check before you register.

  2. 2
    Register on the CEOE site

    Create an account at ceoe.nesinc.com, choose your test and an appointment, and pay when you register.

  3. 3
    Prepare with the official study guide

    The study guide lists every competency and its weight, and the site offers a practice test for many fields.

Fees

$118 (Test fee). Fees can change, so confirm the amount on the CEOE site when you register.

Test day

OSAT tests are part of the Certification Examinations for Oklahoma Educators (CEOE) and are scheduled through the CEOE site (ceoe.nesinc.com), run by Pearson for the Oklahoma Office of Educational Quality and Accountability (OEQA).

Most OSAT tests are computer-based and are offered by appointment year round, Monday through Saturday (excluding some holidays), at test centers in Oklahoma and nationwide. Many can also be taken online with a proctor during one-week testing windows each month, so you can test remotely, including from home. Every appointment includes a 15-minute tutorial and nondisclosure agreement that is not part of the testing time. At a test center, restroom breaks are allowed but count against testing time; online proctoring allows no breaks.

Some tests, such as Advanced Mathematics (211), are offered only at specific test centers. Read the CEOE testing policies for arrival, identification and online proctoring requirements before your appointment.

Scoring

Scores are reported on a scale of 100 to 300, and the passing score is 240 for the OSAT tests on this site.

Selected-response questions are machine scored. Where a test includes a constructed-response assignment, qualified Oklahoma educators score it, and the selected-response and constructed-response parts are weighted by the percentages shown for each subarea.

Who Takes OSAT Biological Sciences (110)?

Candidates seeking Oklahoma certification in Biological Sciences. The OSDE decides which tests a certificate requires, so confirm with it or your preparation program that test 110 applies to you.

Teacher candidates preparing in Biological Sciences. Use the 11 competencies as a checklist of what to review before test day.

How to Prepare for OSAT Biological Sciences (110)

  1. 1
    Start with the official preparation materials

    Read the official CEOE study guide for field 110. It lists each subarea and competency and includes sample questions.

  2. 2
    Study by weight

    Give the most time to Structures and Processes of Cells and Organisms (about 33%), but cover every category.

  3. 3
    Practice at the exam pace

    You have about 2 minutes 58 seconds per item on average (4 hours for 81 items). Practice at that pace so time does not decide your result.

  4. 4
    Weights guide your review

    The largest subarea is Structures and Processes of Cells and Organisms, at 33% of the test. Spend review time in proportion to the weights, but cover every subarea.

  5. 5
    Use the competencies as a checklist

    The study guide lists 11 competencies. For each one, check whether you can explain it without notes and start with the ones you cannot.

  6. 6
    Read the verb in each competency

    1 of the 11 competencies begin with a verb such as Apply, Analyze, Evaluate or Demonstrate. Those signal items that ask you to use a concept in a scenario, so practice with worked examples and not only definitions.

  7. 7
    Use the official practice materials

    Registration includes access to a free online practice test, and the study guide has sample selected-response questions and a sample constructed-response assignment. Work through them to learn the item style before you test.

  8. 8
    Practice the constructed response

    The constructed-response assignment counts for 15% to 20% of your score, so practice writing a focused, supported answer within the time limit.

OSAT Biological Sciences (110): Frequently Asked Questions

What is the passing score for OSAT Biological Sciences (110)?+

A scaled score of 240 (scale 100 to 300).

What is on OSAT Biological Sciences (110)?+

80 selected-response questions and 1 constructed-response assignment, in 4 hours.

How much does OSAT Biological Sciences (110) cost?+

$118 (Test fee). Fees can change, so confirm the amount on the official site.

How many items are on OSAT Biological Sciences (110) and how long is it?+

80 selected-response questions and 1 constructed-response assignment, with 4 hours of testing time plus a 15-minute tutorial.

Which subarea carries the most weight on field 110?+

Structures and Processes of Cells and Organisms, at about 33% of the test.

How many competencies are on field 110?+

The official study guide lists 11 competencies, from 0001 to 0011.

What does the Structures and Processes of Cells and Organisms subarea cover on OSAT Biological Sciences (110)?+

It makes up about 33% of the test and covers competencies 0001–0004: Understand the characteristics and biochemistry of the atoms and molecules necessary for life; Understand the characteristics of cells and their structures and processes; Understand photosynthesis, cellular respiration, and the flow of energy and matter in cells; Understand organismal maintenance, growth, and reproduction.

What does the Ecosystem Energy Flow, Interactions, and Dynamics subarea cover on OSAT Biological Sciences (110)?+

It makes up about 26% of the test and covers competencies 0005–0007: Understand the characteristics of biomes, ecosystems, and their inhabitants; Understand the flow of matter and energy in organisms and ecosystems; Understand the impact of human activities on the environment and society.

What does the Heredity and Evolution subarea cover on OSAT Biological Sciences (110)?+

It makes up about 26% of the test and covers competencies 0008–0010: Understand the molecular basis of inheritance; Understand the inheritance and variation of traits; Understand natural selection, adaptation, and the diversity of life.

What does the Constructed-Response Assignment subarea cover on OSAT Biological Sciences (110)?+

It makes up about 15% of the test and covers competency 0011: Analyze a lesson plan and student work sample for a learning standard in the Oklahoma Academic Standards for Science or the Next Generation Science Standards and describe differentiated instructional strategies that address student needs.

Can I take OSAT Biological Sciences (110) with online proctoring?+

Yes. You can test remotely, including from home, with an online proctor. Online proctoring has no breaks, and its appointment is 3 hours and 15 minutes including the tutorial.

What is the passing score on the OSAT?+

The passing score is 240 on a scale of 100 to 300 for the OSAT tests on this site.

Do OSAT tests include a written part?+

Many do. Early Childhood Education (205), English (207), Advanced Mathematics (211), Mild-Moderate Disabilities (129), Principal Comprehensive Assessment (144), U.S. History/Oklahoma History/Government/Economics (117), Biological Sciences (110), Chemistry (104), Physics (114), World History/Geography (118), Earth Science (108), Physical Science (113), Middle Level/Intermediate Mathematics (225), Middle Level English (124), Middle Level Science (026), Middle Level Social Studies (127), Physical Education/Health/Safety (112), Reading Specialist (115), School Counselor (139), Library-Media Specialist (138), Superintendent (248), Agricultural Education (042), Art (102), Blind/Visual Impairment (128), Business Education (140), Computer Science (181), Dance (178), Deaf/Hard of Hearing (030), Driver/Safety Education (036), Family and Consumer Sciences (109), Gifted Education (083), English as a Second Language (177), Instrumental/General Music (201), Vocal/General Music (203), Journalism (137), Psychology/Sociology (132), Psychometrist (134), School Psychologist (133), Severe-Profound/Multiple Disabilities (131), Special Education Comprehensive Assessment (085), Speech/Drama/Debate (116), Speech-Language Pathology Assistant (084), Technology Engineering (143) and Elementary Education Subtest 1 (150) each include one constructed-response assignment. The world language tests (Cherokee, Chinese, French, German, Latin, Russian and Spanish) include two, one written and one spoken. Elementary Education Subtest 2 (151) and Marketing Education (041) are all selected-response.

Do I still need the OGET for Oklahoma certification?+

According to the CEOE site, the Oklahoma General Education Test (OGET) has not been a requirement for Oklahoma educator certification since May 5, 2022. Contact the Oklahoma Office of Educator Quality and Accountability or the OSDE with questions about your own certificate.

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Sources: CEOE Biological Sciences (110) study guide: test design and framework; CEOE Biological Sciences (110) test details, fee and passing score; Oklahoma State Department of Education: certification assessments; CEOE: Certification Examinations for Oklahoma Educators; CEOE available practice tests (field list); Oklahoma State Department of Education: certification assessments. Always confirm current requirements, fees and passing scores with the official program before you register.

ApexTeachersPrep is independent and is not affiliated with or endorsed by Oklahoma State Department of Education / NES. Last reviewed: October 30, 2026.

Last Updated: October 30, 2026